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KMID : 0359720100280030203
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Journal of the Korean Neurological Association
2010 Volume.28 No. 3 p.203 ~ p.205
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Isaacs’ Syndrome Associated With Acetylcholine Receptor Antibodies Developed After Removal of Malignant Thymoma
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Seo Jin-Young
Shin Byoung-Soo
Seo Man-Wook
Kim Young-Hyun
Oh Sun-Young
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Abstract
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Isaacs’ syndrome is a rare and heterogeneous syndrome of continuous muscle fiber activity that originates from peripheral nerves. We report a 56-year-old male patient who showed symptoms of Isaacs’ syndrome after the removal of a malignant thymoma. Needle electromyography revealed spontaneously occurring repetitive myokymic discharge in the affected muscles. Acetylcholine receptor (AChR) antibodies were significantly elevated, but clinical and electrophysiologic findings did not indicate the presence of myasthenia gravis. We deduce that in Isaacs’ syndrome, raised AChR antibodies may facilitate rather than inhibit cholinergic action.
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KEYWORD
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Isaacs’s syndrome, Acetylcholine receptor antibody
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